Isoform-specific vasoconstriction induced by Apolipoprotein E and modulation of this effect by Alzheimer's β-amyloid peptide
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Acknowledgements
We extend our gratitude to Diane and Robert Roskamp for their generous support which helped to make this work possible. M. Mullan is a recipient of the Veteran's Administration Merit Award.
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2018, GeneCitation Excerpt :Because TSA are absent in the previous meta-analyses (Niu and Qi, 2011; Niu et al., 2009; Stoumpos et al., 2013), we found that Z-curve crossed the trial sequential monitoring boundary using TSA, indicating that this conclusion is reliable. ApoE ε4 allele might promote hypertension via enhancement of vasoconstriction (Paris et al., 1998). High levels of LDL-C in individuals carrying the genotypes (ε3/ε4 and ε4/ε4) reduce endothelium-dependent vasodilatation and increase blood pressure (Uusitupa et al., 1994).
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2015, Trends in NeurosciencesCitation Excerpt :Strikingly, Il10 overexpression increases cerebral Apoe mRNA abundance [43], while Il10 deficiency reduces Apoe expression [37] in mouse models. These findings are particularly interesting because human ApoE isoforms differentially regulate Aβ metabolism, aggregation, deposition, and clearance [54,55], as well as cerebral vasotonus [56]. Knocking in human APOE4 into mouse models of cerebral amyloidosis exacerbates microglial inflammation and Aβ deposition [57], while APOE2 promotes clearance of preexisting deposits [58].
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Significance of Apolipoprotein E in Subarachnoid Hemorrhage: Neuronal Injury, Repair, and Therapeutic Perspectives-A Review
2009, Journal of Stroke and Cerebrovascular DiseasesCitation Excerpt :Previous investigations found that apoE is able to modulate arterial vessel smooth muscle contraction. An in vitro experiment with incubated rat aortic rings demonstrated that apoE4 potentiates ET-1-induced vasoconstriction more than the other variants.76 This observation supports a gain of function theory (as opposed to the loss of function) for the apoE4 in SAH.
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