Brief reportOutcomes of anticoagulated trauma patients☆
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Cited by (45)
The risk of delayed intracranial hemorrhage with direct acting oral anticoagulants after trauma: A two-center study
2019, American Journal of SurgeryCitation Excerpt :In fact, the use of these agents has now surpassed the use of vitamin K antagonists in the United Kingdom and Canada.7,8 Pre-admission anticoagulants may lead to an increased risk for bleeding and other complications following trauma.9 For traumatic brain injuries (TBI) in particular, the use of warfarin prior to admission is associated with an increased risk for injury progression leading to increased mortality, especially in the elderly.10–12
Is There a Need for Platelet Transfusion After TBI in Patients on P2Y12 Inhibitors?
2019, Journal of Surgical ResearchCitation Excerpt :The greatest fear of these medications is the risk of traumatic brain injury (TBI) and the devastating consequences of intracranial hemorrhage (ICH). Most of the previous studies have demonstrated a higher risk of progression of ICH and worse outcomes in patients on antiplatelet therapy who sustain a TBI.3-9 Aspirin is the classic antiplatelet agent and its risk of ICH has been extensively studied in the literature.10,11
Head and Neck Injuries: Special Considerations in the Elderly Patient
2018, Neuroimaging Clinics of North AmericaCitation Excerpt :Current clinical guidelines recommend head CT immediately after admission for all anticoagulated patients with head trauma.1,26 Once intracranial injury has been identified, immediate reversal of coagulopathy is generally warranted despite the potential complications resulting from reversal therapy (including thrombosis and volume overload).1,27,28 A follow-up CT is performed 6 hours after initial diagnosis to evaluate for stability, unless neurologic deterioration prompts earlier reevaluation (Fig. 5).
Antithrombotic agents intake prior to injury does not affect outcome after a traumatic brain injury in hospitalized elderly patients
2017, Journal of Clinical NeuroscienceCitation Excerpt :Benefits of chronic anticoagulation have been documented in some clinical population [7,8] but there is still a lack of consensus regarding the risks of this medication in TBI patients. There are some studies which suggested that mortality and morbidity in elderly patients taking anticoagulation medication is worse than without this pharmacological treatment before trauma [9,10]. A recent study has demonstrated that normalization of International Normalized Ratio (INR) was associated with decreased mortality in isolated TBI patients with acute traumatic anticoagulopathy [11].
The Efficacy of Recombinant Activated Factor VII in Severe Trauma
2009, Annals of Emergency MedicineCitation Excerpt :To remain focused on a patient population that might be considered for treatment with rFVIIa, we addressed specific patient characteristics, including preexisting coagulopathy, mechanism of injury, and severity of injury. We excluded studies that focused on patients with preexisting hypocoagulable states such as hemophilia or patients receiving warfarin because of their biological uniqueness.1,7-10 rFVIIa is licensed and in wide use in patients with hemophilia with inhibitory alloantibodies to factor VIII.1
The effects of preinjury clopidogrel use on older trauma patients with head injuries
2006, American Journal of Surgery
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Presented at the 1997 American College of Emergency Physicians Research Forum, October 18, 1997, San Francisco, CA.