Genetics of infectious disease resistance
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2014, Advances in Virus ResearchCitation Excerpt :The basic types of mapping approaches that have been used are linkage analysis and association studies, which will be discussed later. However, for readers who are interested in more in depth discussion of these approaches, we also refer you to several excellent reviews (Hill, 1996; McCarthy & Hirschhorn, 2008; Suarez & Cox, 1985). As initially conceived, linkage analysis was most appropriate for the identification of highly penetrant, Mendelian genes (e.g., binary traits) segregating within some form of family pedigree or pedigrees.
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