Is postherpetic neuralgia more than one disorder?
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Cited by (60)
Post-herpetic neuralgia
2012, Continuing Education in Anaesthesia, Critical Care and PainCitation Excerpt :However, there is speculation whether these processes occur in humans. PHN patients may be subgrouped into three types based on distinct underlying pain pathophysiology:3 Irritable nociceptors develop secondarily to abnormally functioning primary afferent neurones that generate and maintain pain.
Herpes zoster and postherpetic neuralgia
2011, Essentials of Pain MedicineNatural history of sensory function after herpes zoster
2010, PainCitation Excerpt :In longstanding PHN, Watson reported sensory loss in nearly all 208 patients in his series [39], and Rowbotham and Fields showed allodynia area, allodynia severity, and thermal threshold asymmetry between PHN and mirror-skin to be stable over multiple examinations [31]. Sensory testing, allodynia mapping, response to local anesthetic application, and the capsaicin response test has provided evidence that the pain and allodynia in some patients with longstanding PHN are maintained by ‘irritable’ primary afferent nociceptors connecting painful skin with sensitized central targets [10,28,32]. The relationship between sensory disturbances in the months following the onset of herpes zoster (HZ) and development of PHN is not well understood.
Mechanisms of Pain and Itch Caused by Herpes Zoster (Shingles)
2008, Journal of PainCitation Excerpt :Here, the plasticity would be peripheral rather than central. This was popularized as the “irritable nociceptor” hypothesis.44 Note that this hypothesis is not mutually exclusive with central neuroplasticity.
Facial altered sensation and sensory impairment after orthognathic surgery
2007, International Journal of Oral and Maxillofacial SurgeryCitation Excerpt :Previous studies have also shown that patients with neuropathic pain, secondary to damage of the trigeminal or spinal nerves, can be either hyposensitive or hypersensitive to mechanical stimulation of the skin. Combining their threshold values in clinical studies is known to mask differences in sensory function (i) between patients and control subjects1,22 and (ii) between affected and non-affected sides of the patient's body4,17. The distinction offered by consideration of patients’ altered sensation is also prognostic for the individual patient.