Case report
Status dystonicus in tardive dystonia successfully treated by bilateral deep brain stimulation

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Case report

We present the case of an 18-year-old boy, who was treated by risperidon (up to 8 mg/day) and clonazepam (up to 4 mg/day) combination because of schizophrenia since the age of 16. Due to an acute psychotic episode up to 5 mg/day haloperidol was introduced as an add-on therapy to risperidon resulting in acute oculogyric symptoms in July, 2009. After a usage of 16 days, the haloperidol medication was completely stopped, whereas biperiden (2 mg tid) was introduced. Subsequently, risperidon was also

Discussion

Dopamine-receptor-blocking antipsychotic drugs may cause various acute and delayed-onset movement disorders including acute dystonia, parkinsonism, akathisia, tardive dyskinesia and tardive dystonia. Despite tardive movement disorders were described 50 years ago, their medical treatment is still disappointing in some cases. However, a growing number of evidence suggests that tardive dystonia and/or dyskinesia might be an excellent indication for bilateral GPi-DBS with an improvement of 65–100%

Financial disclosure

NK and JJ are supported by a government based Bolyai Scholarship of the Hungarian Scientific Academy. NK, JJ, MS, SK, SF received a grant from Norwegian Financial Mechanism (HU00114) of European Union. NK also received a support from the Hungarian Neuroimaging Foundation. JJ was supported by Hungarian Research Fund (OTKA-NKTH F68720).

Declaration of interests

Dr. Kovacs is supported by the government-based Bolyai Scholarship of the Hungarian Scientific Academy, and a grant from Norwegian Financial Mechanism (HU00114) of European Union, and he also received a grant from the Hungarian Neuroimaging Foundation.

Dr. Balas reported no financial disclosure.

Dr. Janszky is supported by the government-based Bolyai Scholarship of the Hungarian Scientific Academy, Hungarian Research Fund (OTKA-NKTH F68720) and a grant from Norwegian Financial Mechanism (HU00114)

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