Letter to the EditorHelicobacter pylori and multiple sclerosis
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Cited by (46)
The trimebutine effect on Helicobacter pylori-related gastrointestinal tract and brain disorders: A hypothesis
2021, Neurochemistry InternationalCitation Excerpt :Whether this coexistence of GIT dysbiosis is etiologically relevant to the development of central nervous system (CNS) diseases, or it is circumstantial, remains to be further elucidated; however, clinical and experimental evidence underline the capacity of microbes to elicit systemic immune responses with a potential to trigger CNS autoimmunity. We previously reported an association between Helicobacter pylori infection (Hp-I) and several neurodegenerative and inflammatory diseases, such as AD (Doulberis et al., 2018, 2020a; Kountouras et al., 2006, 2019a), open–angle glaucoma (OAG) (termed as “ocular” AD) (Papaefthymiou et al., 2020), mild cognitive impairment (MCI) (Kountouras et al., 2007a), MS (Gavalas et al., 2007; Kountouras et al., 2020c), and clinically isolated syndrome (CIS) (Deretzi et al., 2015). Likewise, Hp-I has also been linked with MetS, insulin resistance and associated morbidity, such as cardio-cerebrovascular disease and neurodegenerative disorders (Kountouras et al., 2017, 2018c, 2020a).
Helicobacter pylori infection as a potential risk factor for multiple sclerosis
2020, Medical HypothesesCitation Excerpt :We hypothesize thus, that humoral and cellular immune responses by active Hp-I, apart from damaging locally the gastric mucosa, they may shape the character of systemic autoimmune responses, contributing to MS. We conducted previously two pilot investigations [32,33]. The aim of these pilot studies was to evaluate the presence of active Hp-I in MS patients, and thus its potential involvement in MS pathophysiology.
Helicobacter pylori infection and demyelinating disease of the central nervous system
2019, Journal of NeuroimmunologyA potential impact of Helicobacter pylori-related galectin-3 in neurodegeneration
2018, Neurochemistry InternationalCitation Excerpt :Gut microflora alters the intestinal barrier integrity and modulates systemic innate immunity responses (McDermott and Huffnagle, 2014; Ochoa-Reparaz and Kasper, 2016; Yacyshyn et al., 1996), shedding light on the complex aspect of microbiota – host interaction and the gut-brain interplay (Gupta et al., 2005). Some data showed epidemiological evidence of Hp infection increased prevalence in a variety of the mentioned CNS autoimmune and degenerative disorders including neuromyelitis optica (NMO) (Kountouras et al., 2010b; Li et al., 2009; Long et al., 2013), glaucoma (Kountouras et al., 2007d), AD (Kountouras et al., 2006a, 2010a; Malaguarnera et al., 2004), MCI (Kountouras et al., 2007c), PD (Mridula et al., 2017), CIS (Deretzi et al., 2016) and MS (Efthymiou et al., 2016; Gavalas et al., 2007; Kountouras et al., 2008a; Long et al., 2013), indicating a potential Hp detrimental role in neurodegeneration. Hp elicits inflammatory reactions in absence of gastric ulcer disease and although the Hp and gut microbiota interaction in regulating host metabolism remains unidentified, gastric and fecal microbiota have been changed in Hp-infected individuals and mice to promote gastric inflammation and specific diseases (Yang and Sheu, 2016).
Meta-analysis of association between Helicobacter pylori infection and multiple sclerosis
2016, Neuroscience LettersA proposed role of human defensins in Helicobacter pylori-related neurodegenerative disorders
2014, Medical HypothesesCitation Excerpt :Of note, iron is important for almost all living organisms and the investigation of iron uptake and trafficking system is thus essential to understand the pathological roles of H. pylori. We also reported a strong association between H. pylori infection and MS in a Greek cohort [45,46]. Besides, an association between H. pylori infection and primary open-angle glaucoma (POAG) patients in a Greek cohort has been found; H. pylori eradication may positively influence glaucoma progression; and H. pylori-specific IgG antibody levels are significantly increased in the aqueous humour of patients with POAG; the concentration of this antibody correlates with the degree of vertical cupping, possibly indicating the severity of glaucomatous damage.