Neuron
Volume 71, Issue 6, 22 September 2011, Pages 955-957
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Wnt Signaling as a Potential Therapeutic Target for Frontotemporal Dementia

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Progranulin mutations result in frontotemporal dementia, but the underlying pathophysiology has remained largely unexplained. New data by Geschwind and colleagues in this issue of Neuron uncovered that the Wnt/FZD2 signaling pathway is an early and critical contributor to disease pathology.

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