Original ArticleMultifocal Visual Evoked Potential Analysis of Inflammatory or Demyelinating Optic Neuritis
Section snippets
Subjects and Methods
Sixty-four subjects (mean age, 34.8 ±11.1 years) with inflammatory or demyelinating ON were recruited from the Sydney Eye Hospital and St. Vincent’s Hospital. Each patient had a diagnosis of either acute or previous optic neuritis (with unilateral visual loss, afferent papillary defect, and pain on eye movement) confirmed by a consultant neuro-ophthalmologist. The time from onset of optic neuritis was recorded (mean, 16.6 months; range, 15 days–5 years). Several patients had a history of past
Amplitude
Table 1 shows the number of ON eyes with an amplitude abnormality on mVEP.
As can be seen from the table, the percentage of eyes with an amplitude deviation scotoma is increased in the MS groups compared with the other groups. There were no amplitude abnormalities seen in the control group. Within the not-MS and possible MS groups, only approximately 70% of the eyes showed an amplitude deviation with respect to the normal population; however nearly 90% had intereye amplitude asymmetry, which
Discussion
This is the first study that has examined the sensitivity of the multifocal VEP technique in a large number of patients with ON classified according to the McDonald criteria. The separation of ON patients into groups with MS, possible MS, and not-MS provided a basis from which to analyze amplitude and latency results that have not been used with full-field conventional VEP studies to our knowledge.
Previous VEP studies on inflammatory ON and MS have often reported conflicting results, which to
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Cited by (0)
Manuscript no. 2005-436.
Supported by University of Sydney, Sydney, Australia (University Postgraduate Scholarship).
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Drs Klistorner and Graham have a financial interest in the Accumap, being coinventors of the machine and acting as consultants to ObjectiVision, Sydney, Australia. They are both involved in the ongoing research and development of the product.