Factors related to clinically probable REM sleep behavior disorder in Parkinson disease☆
Section snippets
Subjects and methods
The study subjects included 447 consecutive patients with PD (mean age, 63.8 ± 9.2 yrs; 207 men and 240 women) who visited our hospital from March 1 to June 30, 2007. All subjects gave their written informed consent to participate in this study after a full explanation of the purpose and a detailed description of the study procedures. This study was approved by the Institutional Review Board of our hospital. All PD diagnoses were made according to the United Kingdom Brain Bank criteria [16].
All
Results
During face-to-face interviews, 164 of 447 PD patients (36.7%) were diagnosed with cpRBD. RLS was diagnosed in 73 patients (16.3%). The demographic characteristics of the patients are shown in Table 1. Patients with cpRBD were older, had a longer duration of PD symptoms, more severe PD disability as assessed by either Hoehn and Yahr stage or UPDRS, higher bradykinesia and axial/gait scores, a lower proportion of their UPDRS score accounted for by tremor, and a longer duration of
Discussion
The present study used the minimal diagnostic criteria for parasomnias provided in the ICSD-R, which includes the presence of limb or body movements associated with dream mentation, and at least one of the following criteria: harmful or potentially harmful sleep behaviors, dreams appearing to be “acted out”, and sleep behaviors disrupting sleep continuity [17]. The latest version of ICSD criteria has added polysomnography (PSG) recording as a mandatory criteria, because PSG is the only method
Acknowledgement
This research was supported by the Brain Korea 21 Project for Medical Science, Yonsei University.
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The review of this paper was entirely handled by an Associate Editor, En-King Tan.