Cell Stem Cell
ArticleLRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
Highlights
► iPSC derived from a PD patient differentiated into midbrain dopaminergic neurons ► Generated neurons show accumulation of α-synuclein and increased oxidative stress ► PD-neurons are more susceptible to H2O2-induced CASP3 activation and death ► PD-neurons are more sensitive to toxicity from 6-OHDA and proteasome inhibition
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Present address: Department of Molecular and Medical Pharmacology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research University of California, Los Angeles, CA 90095, USA
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Present address: School of Medicine, Tsinghua University, Beijing 100084, China
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Present address: Johns Hopkins School of Medicine, Cell and Molecular Medicine Program, Baltimore, MD 21205, USA
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These authors contributed equally to this work