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Clinically diagnosed presenile dementia of the Alzheimer type in the Northern Health Region: ascertainment, prevalence, incidence and survival

Published online by Cambridge University Press:  09 July 2009

A. J. Newens ,
D. P. Forster ,
D. W. K. Kay ,
W. Kirkup ,
D. Bates  and
J. Edwardson
A. J. Newens
Affiliation:
Division of Epidemiology and Public Health, University of Newcastle upon Tyne; MRC Neurochemical Pathology Unit, Newcastle General Hospital; and Department of Neurology, Royal Victoria Infirmary, Newcastle upon Tyne
D. P. Forster*
Affiliation:
Division of Epidemiology and Public Health, University of Newcastle upon Tyne; MRC Neurochemical Pathology Unit, Newcastle General Hospital; and Department of Neurology, Royal Victoria Infirmary, Newcastle upon Tyne
D. W. K. Kay
Affiliation:
Division of Epidemiology and Public Health, University of Newcastle upon Tyne; MRC Neurochemical Pathology Unit, Newcastle General Hospital; and Department of Neurology, Royal Victoria Infirmary, Newcastle upon Tyne
W. Kirkup
Affiliation:
Division of Epidemiology and Public Health, University of Newcastle upon Tyne; MRC Neurochemical Pathology Unit, Newcastle General Hospital; and Department of Neurology, Royal Victoria Infirmary, Newcastle upon Tyne
D. Bates
Affiliation:
Division of Epidemiology and Public Health, University of Newcastle upon Tyne; MRC Neurochemical Pathology Unit, Newcastle General Hospital; and Department of Neurology, Royal Victoria Infirmary, Newcastle upon Tyne
J. Edwardson
Affiliation:
Division of Epidemiology and Public Health, University of Newcastle upon Tyne; MRC Neurochemical Pathology Unit, Newcastle General Hospital; and Department of Neurology, Royal Victoria Infirmary, Newcastle upon Tyne
*
1Address for correspondence: Dr D. P. Forster, Division of Epidemiology and Public Health, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH.
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Synopsis

Potential cases of presenile dementia of the Alzheimer type (PDAT) in the Northern Health Region (estimated population aged 45–64, 655800) were ascertained for the years 1979–86 from in-patient ICD-9 codes and other sources. An algorithm was applied to the casenote information to distinguish between Alzheimer-type and other forms of dementia. A search of the NHS central register was made to establish date and place of death. Estimates were made for patients with missing case records. The point prevalence rate for PDAT was estimated as 34·6 per 100000 with an annual incidence of 7·2 per 100000 in the 45–64 age range. These rates are compared with those reported in other studies. Five-year survival following diagnosis for incident cases of PDAT was 64% with a longevity quotient (LQ), the percentage of expected time actually survived, of 69%. There was no evidence of a more malignant course in PDAT when compared with survival in older patients with dementia of the Alzheimer type (DAT) in other studies. Sixty-six per cent of deaths occurred in hospital, 19% at home and 15% in residential homes.

Type
Original Articles
Information
Psychological Medicine , Volume 23 , Issue 3 , August 1993 , pp. 631 - 644
Copyright
Copyright © Cambridge University Press 1993

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