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Multiple sclerosis and human T-cell lymphotropic retroviruses

Abstract

A combination of different types of data suggests that some multiple sclerosis patients respond immunologically to, and have cerebrospinal T cells containing, a retrovirus that is related to, but distinct from, the three types of human T-cell lymphotropic viruses. The role of this virus in multiple sclerosis is uncertain.

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References

  1. Poiesz, B.J. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7415–7419 (1980).

    Article  ADS  CAS  Google Scholar 

  2. Sandberg-Wollheim, M. Scand J. Immun. 17, 575–581 (1983).

    Article  CAS  Google Scholar 

  3. Cashman, N., Martin, C., Eizenbaum, J.F., Degos, J.D. & Bach, M.A. J. clin. Invest. 70, 387–392 (1982).

    Article  CAS  Google Scholar 

  4. Link, H. et al. Acta neurol. scand. 55, 173–189 (1977).

    Google Scholar 

  5. Guseo, A. & Jellinger, K. J. Neurol. 211, 51–60 (1974).

    Article  Google Scholar 

  6. Gallo, C. Cancer Surv. 3(1), 113–159 (1984).

    Google Scholar 

  7. Popovic, M., Sarngadharan, M. G., Read, E. & Gallo, R. C. Science 224, 497–500 (1984).

    Article  ADS  CAS  Google Scholar 

  8. DeFreitas, E., Sandberg-Wollheim, M., Schonely, K. & Koprowski, H. Proc. natn. Acad. Sci. U.S.A. (submitted).

  9. Shaw, G. M. et al. Science 227, 177–182 (1985).

    Article  ADS  CAS  Google Scholar 

  10. Ho, D. D. et al. New Engl. J. Med. (in the press).

  11. Broman, T., Andersen, O. & Bergmann, L. Acta neurol. scand. 63(1), 6–33 (1981).

    Article  CAS  Google Scholar 

  12. Kinnunen, E. Neurology 34, 457–461 (1984).

    Article  CAS  Google Scholar 

  13. Larsen, J.P., Riise, T., Kvaale, G., Nyland, H. & Aarli, J.A. Acta neurol. scand. 69, Suppl. 98, 372–373 (1984).

    Article  Google Scholar 

  14. Sheremata, W. A., Poskanzer, D. C., Withum, D. G., MacLeod, C. L. & Whiteside, M. E. Lancet ii, 618 (1985).

    Article  Google Scholar 

  15. Harper, M., Marselle, L., Wong-Staal, F. & Gallo, R. C. Proc. natn. Acad. Sci. (in the press).

  16. McDonald, W. E. & Halliday, A. M. Br. med. Bull. 33, 4–9 (1977).

    Article  CAS  Google Scholar 

  17. Kalyanaraman, V. S., Sarngadharan, M. G., Poiesz, B., Ruscetti, F. W. & Gallo, R. C. J. Virol. 81, 906–915 (1981).

    Google Scholar 

  18. Ryberg, B., Nilsson, B., Burgdorfer, W. & Barbour, A. G. Lancet ii, 519 (1983).

    Article  Google Scholar 

  19. Saxinger, W. C. & Gallo, R. C. Lab. Invest. 49, 371–377 (1983).

    CAS  PubMed  Google Scholar 

  20. Sarngadharan, M. G., Popovic, M., Bruch, L., Schupbach, J. & Gallo, R. C. Science 224, 506–508 (1984).

    Article  ADS  CAS  Google Scholar 

  21. Robert-Guroff, M. et al. Science 215, 975–978 (1982).

    Article  ADS  CAS  Google Scholar 

  22. Laurell, C.-B. Scand. J. clin. Lab. Invest. 29, Suppl. 124, 21–37 (1972).

    Article  CAS  Google Scholar 

  23. Olsson, J.-E. & Pettersson, B. Acta neurol. scand. 53, 308–322 (1976).

    Article  CAS  Google Scholar 

  24. Reiber, H. J. Neurol. 224, 89–99 (1980).

    Article  CAS  Google Scholar 

  25. Norrby, E. Prog. med. Virol. 24, 1–39 (1978).

    CAS  PubMed  Google Scholar 

  26. Arnadottir, T. et al. Archs Neurol. 36, 261–265 (1979).

    Article  CAS  Google Scholar 

  27. Sarngadharan, M. G., Bruch, L., Popovic, M. & Gallo, R. C. Proc. natn. Acad. Sci. U.S.A. 82, 3481–3484 (1985).

    Article  ADS  CAS  Google Scholar 

  28. Brahic, M., Stowring, L., Ventura, P. & Haase, A. T. Nature 292, 240–242 (1981).

    Article  ADS  CAS  Google Scholar 

  29. Stowring, L. et al. Virology 141, 311–318 (1985).

    Article  CAS  Google Scholar 

  30. Miyoshi, I. et al. Nature 294, 770–771 (1981).

    Article  ADS  CAS  Google Scholar 

  31. Markham, P. D. et al. Int. J. Cancer 31, 413–420 (1981).

    Article  Google Scholar 

  32. Salahuddin, S. Z. et al. Lancet ii, 1418–1420 (1984).

    Article  Google Scholar 

  33. Groopman, J. E. et al. Ann. intern. Med. 102, 63–66 (1985).

    Article  CAS  Google Scholar 

  34. Kalyanaraman, V. S. et al. Science 218, 571–573 (1982).

    Article  ADS  CAS  Google Scholar 

  35. Gelmann, E. P., Franchini, G., Manzari, V., Wong-Staal, F. & Gallo, R. C. Proc. natn. Acad. Sci. U.S.A. 81, 993–997 (1984).

    Article  ADS  CAS  Google Scholar 

  36. Takatsuki, K. et al. Gann 28, 13–22 (1982).

    Google Scholar 

  37. Dean, G. & Kurtzke, J.F. Br. med. J. 3, 725–729 (1971).

    Article  CAS  Google Scholar 

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Koprowski, H., DeFreitas, E., Harper, M. et al. Multiple sclerosis and human T-cell lymphotropic retroviruses. Nature 318, 154–160 (1985). https://doi.org/10.1038/318154a0

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