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A gene for familial hemiplegic migraine maps to chromosome 19

Nature Genetics volume 5, pages 40–45 (1993)Cite this article

Abstract

Familial hemiplegic migraine is an autosomal dominant disorder of unknown pathogenesis in which the migrainous attacks are marked by the occurrence of a transient hemiplegia during the aura. While investigating CADASIL, mapped previously to chromosome 19, we observed that some patients had recurrent attacks of migraine with aura. Although the clinical and neuroimaging features of familial hemiplegic migraine differ markedly from CADASIL, we hypothesized that the same gene could be involved in the pathogenesis of both conditions. We chose two large pedigrees for linkage analysis of familial hemiplegic migraine. A maximum lod score > 8 was found with two markers that are also strongly linked to CADASIL Multilocus linkage analysis suggested that the loci responsible for the two diseases reside within an interval of about 30 cM on chromosome 19.

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References

  1. Stewart, W.F., Lipton, R.B., Celentano, D.D. & Reed, M.L. Prevalence of migraine headache in the United States. JAMA 267, 64–69 (1992).

    Article  CAS  PubMed  Google Scholar 

  2. Henry, P., Michel, P., Dartigues, J.F., Tison, F. & Vivares, C. Epidémiologie de la maladie migraineuse. Circ. Métab. du Cerv. 7, 229–236 (1990).

    Google Scholar 

  3. Lance, J.W. Mechanism and management of headache 4th edn (Butterworths Scientific, London, 1982).

    Google Scholar 

  4. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 8, Supp. 7 19–28 (1988).

  5. Blau, J.N. & Whitty, C.W.M. Familial hemiplegic migraine. Lancet 2, 1115–1116 (1955).

    Article  Google Scholar 

  6. Clarke, J.M. On recurrent motor paralysis in migraine. Br. Med. J. 1, 1534–1538 (1910).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Glista, G. & Mellinger, J.F. Familial hemiplegic migraine. Mayo Clin. Proc. 50, 307–311 (1975).

    CAS  PubMed  Google Scholar 

  8. Whitty, C.W.M. Familial hemiplegic migraine. J.Neurol. Neurosurg. Psychiatry 16, 172–177 (1953).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Münte, T.F. & Müller-Vahl, H. Familial migraine coma: a case study. J. Neurol. 237, 59–61 (1990).

    Article  PubMed  Google Scholar 

  10. Fitzimons, R.B. & Wolfenden, W.H. Migraine coma. Meningitic migraine with cerebral oedema associated with a new form of autosomal dominant cerebellar ataxia. Brain 108, 555–577 (1985).

    Article  Google Scholar 

  11. Young, G.F. et al. Familial hemiplegic migraine, retinal degeneration, deafness, and nystagmus. Arch. Neurol. 23, 201–209 (1970).

    Article  CAS  PubMed  Google Scholar 

  12. Zifkin, B., Andermann, E., Andermann, F. & Kirkham, T. An autosomal dominant syndrome of hemiplegic migraine, nystagmus, and tremor. Ann. Neurol. 8, 329–332 (1980).

    Article  CAS  PubMed  Google Scholar 

  13. Ohta, M., Araki, S. & Kuroiwa, Y. Familial occurence of migraine with a hemiplegic syndrome and cerebellar manifestations. Neurology 17, 813–817 (1967).

    Article  CAS  PubMed  Google Scholar 

  14. Codina, A., Acarini, P.N. & Miguel, F. Migraine hémiplégique associée à un nystagmus. Rev. Neurol. (Paris) 124, 526–530 (1971).

    CAS  PubMed  Google Scholar 

  15. Tournier-Lasserve, E., Iba-Zizen, M.T., Romero, N. & Bousser, M.G. Autosomal dominant syndrome with stroke-like episodes and leukoencephalopathy. Stroke 22, 1297–1302 (1991).

    Article  CAS  PubMed  Google Scholar 

  16. Baudrimont, M., Dubas, F., Joutel, A., Tournier-lasserve, E. & Bousser, M.G. Autosomal dominant leukoencephalopathy and subcortical ischemic stroke : a clinicopathological study. Stroke 24, 122–125 (1993).

    Article  CAS  PubMed  Google Scholar 

  17. Tournier-Lasserve, E. et al. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12. Nature Genet. 3, 256–259 (1993).

    Article  CAS  PubMed  Google Scholar 

  18. Pages, M., Barège, M., Blard, J.M. & Labauge, R. La migraine hémiplégique familiale. Sem. Hôp. Paris. 12, 337–342 (1993).

    Google Scholar 

  19. Weissenbach, J. & et al. A second generation linkage map of the human genome. Nature 359, 794–801 (1992).

    Article  CAS  PubMed  Google Scholar 

  20. Lathrop, G.M., Lalouel, J.M., Julier, C. & Ott, J. Multilocus linkage analysis in humans: detection of linkage and estimation of recombination. Am. J. hum. Genet. 37, 482–498 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratoire de Pathologie de l'Immunité, Faculté de Médecine Necker, Enfants-Malades, 156 rue de Vaugirard, 75730, Paris, Cedex 15, France

    Anne Joutel, Hugues Chabriat, Argentino Nibbio, Jacqueline Maciazek, Bénédicte Meyer, Marie-Anne Bach & Elisabeth Tournier-Lasserve

  2. Service de Neurologie, Hopital St Antoine, Paris, France

    Anne Joutel, Marie-Germaine Bousser, Valérie Biousse & Hugues Chabriat

  3. Clinique Neurologique du C.H. et U, Montpellier-Nîmes, France

    Pierre Labauge

  4. Unité de Génétique Moléculaire Humaine (CNRS URA 1445) Institut Pasteur, Paris, France

    Jean Weissenbach

  5. Généthon, 91000, Evry, France

    Jean Weissenbach

  6. Unité INSERM U358, CEPH, Paris, France

    G. Mark Lathrop

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  1. Anne Joutel
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  2. Marie-Germaine Bousser
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  3. Valérie Biousse
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  4. Pierre Labauge
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  6. Argentino Nibbio
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  7. Jacqueline Maciazek
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  8. Bénédicte Meyer
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  9. Marie-Anne Bach
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  10. Jean Weissenbach
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  11. G. Mark Lathrop
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  12. Elisabeth Tournier-Lasserve
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Joutel, A., Bousser, MG., Biousse, V. et al. A gene for familial hemiplegic migraine maps to chromosome 19. Nat Genet 5, 40–45 (1993). https://doi.org/10.1038/ng0993-40

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