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Treatment of multiple sclerosis with T–cell receptor peptides: Results of a double–blind pilot trial

Nature Medicine volume 2, pages 1109–1115 (1996)Cite this article

Abstract

A T–cell receptor (TCR) peptide vaccine from the Vβ5.2 sequence expressed in multiple sclerosis (MS) plaques and on myelin basic protein (MBP)–specific T cells boosted peptide–reactive T cells in patients with progressive MS. Vaccine responders had a reduced MBP response and remained clinically stable without side effects during one year of therapy, whereas nonresponders had an increased MBP response and progressed clinically. Peptide–specific T helper 2 cells directly inhibited MBP–specific T helper 1 cells in vitro through the release of interleukin–10, implicating a bystander suppression mechanism that holds promise for treatment of MS and other autoimmune diseases.

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Authors and Affiliations

  1. Neuroimmunology Research 151D, Veterans Affairs Medical Center, 3710 SW Veterans Hospital Road, Portland, Oregon, 97201, USA

    Arthur A. Vandenbark, Ruth Whitham, Daniel Kavanagh, Halina Offner & Dennis N. Bourdette

  2. Department of Neurology, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97201, USA

    Arthur A. Vandenbark, Yuan K. Chou, Ruth Whitham, Michele Mass, Abigail Buenafe, Diane Liefeld, Shelley Cooper, Halina Offner & Dennis N. Bourdette

  3. Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97201, USA

    Arthur A. Vandenbark

  4. Council for Tobacco Research, 900 Third Avenue, New York, New York, 10022, USA

    George A. Hashim

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Vandenbark, A., Chou, Y., Whitham, R. et al. Treatment of multiple sclerosis with T–cell receptor peptides: Results of a double–blind pilot trial. Nat Med 2, 1109–1115 (1996). https://doi.org/10.1038/nm1096-1109

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