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Midbrain serotonergic neurons are central pH chemoreceptors

Abstract

Serotonergic neurons in the medulla are central respiratory chemoreceptors. Here we show that serotonergic neurons in the midbrain of rats are also highly chemosensitive to small changes in CO2/pH and are closely associated with large penetrating arteries. We propose that midbrain raphé neurons are sensors of blood CO2 that maintain pH homeostasis by inducing arousal, anxiety and changes in cerebrovascular tone in response to respiratory acidosis.

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Figure 1: Midbrain serotonergic neurons are pH chemosensitive.
Figure 2: Midbrain serotonergic neurons are closely associated with large arteries.
Figure 3: Acidosis-stimulated neurons next to arteries were serotonergic.

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References

  1. Jacobs, B.L. & Azmitia, E.C. Physiol. Rev. 72, 165–229 (1992).

    Article  CAS  Google Scholar 

  2. Jacobs, B.L. & Fornal, C.A. Curr. Opin. Neurobiol. 7, 820–825 (1997).

    Article  CAS  Google Scholar 

  3. Azmitia, E.C. Neuropsychopharmacology 21, S33–S45 (1999).

    Article  Google Scholar 

  4. Bradley, S.R. et al. Nat. Neurosci. 5, 401–402 (2002).

    Article  CAS  Google Scholar 

  5. Wang, W., Zaykin, A.V., Tiwari, J.K., Bradley, S.R. & Richerson, G.B. J. Neurophysiol. 85, 2224–2235 (2001).

    Article  CAS  Google Scholar 

  6. Veasey, S.C., Fornal, C.A., Metzler, C.W. & Jacobs, B.L. Neuroscience 79, 161–169 (1997).

    Article  CAS  Google Scholar 

  7. Veasey, S.C., Fornal, C.A., Metzler, C.W. & Jacobs, B.L. J. Neurosci. 15, 5346–5359 (1995).

    Article  CAS  Google Scholar 

  8. Scheibel, M.E., Tomiyasu, U. & Scheibel, A.B. Exp. Neurol. 47, 316–329 (1975).

    Article  CAS  Google Scholar 

  9. Berry, R.B. & Gleeson, K. Sleep 20, 654–675 (1997).

    Article  CAS  Google Scholar 

  10. Klein, D.F. Archiv. Gen. Psychiatry 50, 306–317 (1993).

    Article  CAS  Google Scholar 

  11. Eldridge, F.L. & Waldrop, T.G. in Exercise: Pulmonary Physiology and Pathophysiology (eds. Whipp, B.J. & Wasserman, K.) 309–359 (Marcel Dekker, NewYork, 1991).

    Google Scholar 

  12. Kinney, H.C., Filiano, J.J. & White, W.F. J. Neuropathol. Exp. Neurol. 60, 228–247 (2001).

    Article  CAS  Google Scholar 

  13. Grove, G., Coplan, J.D. & Hollander, E. J. Neuropsychiatry Clin. Neurosci. 9, 198–207 (1997).

    Article  CAS  Google Scholar 

  14. Gorman, J.M., Liebowitz, M.R., Fyer, A.J. & Stein, J. Am. J. Psych. 146, 148–161 (1989).

    Article  CAS  Google Scholar 

  15. Weiller, C. et al. Nat. Med. 1, 658–660 (1995).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the US National Institutes of Health (C.A.S., W.W., V.A.P. & G.B.R.), the Department of Veterans Affairs (G.B.R.) and the German Merit Foundation (C.I.D.).

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Correspondence to George B Richerson.

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Severson, C., Wang, W., Pieribone, V. et al. Midbrain serotonergic neurons are central pH chemoreceptors. Nat Neurosci 6, 1139–1140 (2003). https://doi.org/10.1038/nn1130

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