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ICAM-1 is crucial for protection from TMEV-induced neuronal damage but not demyelination

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Abstract

Previous work has suggested that the factors protecting mice from Theiler’s murine encephalomyelitis virus (TMEV)-induced spinal cord demyelination are distinct from those involved in protection of the brain during the acute encephalitic phase. In this study, we examined the requirement for intercellular adhesion molecule-1 (ICAM-1) in both of these processes. During the acute phase of infection (days 7 to 10 after intracerebral infection with TMEV), no differences in brain or spinal cord pathology or virus burdens were observed between ICAM-1-knockout mice and the infected immunocompetent control mice of a similar background. Examination of brain pathology later in infection (that is, day 45 post infection [p.i.]) revealed that ICAM-1-deficient mice experienced increased levels of pathology in gray matter regions of the brain. We observed an increase in striatal damage and meningeal inflammation in the brains of TMEV-infected ICAM-1-knockout mice compared to C57BL/6J mice. Despite the increase in brain pathology, no immunoreactivity to viral antigens was detected, suggesting that the virus had been cleared by this time. Resistance to demyelination was similar in both groups, indicating that the resulting immune response was sufficient for protection of the spinal cord white matter.

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Authors and Affiliations

  1. Department of Medical Microbiology and Immunology, Creighton University, Omaha, Nebraska, USA

    Kristen M. Drescher

  2. Department of Immunology, Mayo Clinic/Foundation, Rochester, Minnesota, USA

    Laurie J. Zoecklein & Moses Rodriguez

  3. Department of Neurology, Mayo Clinic/Foundation, Rochester, Minnesota, USA

    Laurie J. Zoecklein & Moses Rodriguez

Authors
  1. Kristen M. Drescher
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  2. Laurie J. Zoecklein
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  3. Moses Rodriguez
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Corresponding author

Correspondence to Moses Rodriguez.

Additional information

These studies were supported by NIH grants P01NS38468 (MR) and R01 NS32129 (MR), a grant from the Health Futures Foundation (KMD), and the American Cancer Society (KMD).

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Drescher, K.M., Zoecklein, L.J. & Rodriguez, M. ICAM-1 is crucial for protection from TMEV-induced neuronal damage but not demyelination. Journal of NeuroVirology 8, 452–458 (2002). https://doi.org/10.1080/13550280260422767

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  • DOI: https://doi.org/10.1080/13550280260422767

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