Journal of the American Academy of Child & Adolescent Psychiatry
ARTICLERegional Brain Enlargement in Autism: A Magnetic Resonance Imaging Study
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Study subnetwork developing pattern of autism children by non-negative matrix factorization
2023, Computers in Biology and MedicineEvidence for normal extra-axial cerebrospinal fluid volume in autistic males from middle childhood to adulthood
2021, NeuroImageCitation Excerpt :The first three years in human development are incredibly important to the emergence and identification of autistic symptoms (Estes et al., 2015; Landa et al., 2013; Zwaigenbaum et al., 2013). Beyond behavioral markers, many neuroanatomical findings arise during this period, including aberrant white matter integrity in the genu of the corpus callosum and cerebellar peduncles (Shen and Piven, 2017) and enlarged head circumference and brain volume (Aylward et al., 2002; Courchesne et al., 2001; Hardan et al., 2001; Hazlett et al., 2005, 2017; Nordahl et al., 2011; Pardo et al., 2005; Piven et al., 1996; Shen et al., 2013, 2018). This consistent finding of increased brain volume is associated with an increase in cortical surface area, but not cortical thickness (Hazlett et al., 2017).
PM<inf>2.5</inf> as a potential risk factor for autism spectrum disorder: Its possible link to neuroinflammation, oxidative stress and changes in gene expression
2021, Neuroscience and Biobehavioral ReviewsAssociation Between Abnormal Fetal Head Growth and Autism Spectrum Disorder
2021, Journal of the American Academy of Child and Adolescent PsychiatryA voxel-wise assessment of growth differences in infants developing autism spectrum disorder
2021, NeuroImage: ClinicalThree dimensional reconstructions of the superior olivary complex from children with autism spectrum disorder
2020, Hearing ResearchCitation Excerpt :The neuropathological changes that occur in ASD do appear to be region dependent. In particular, there appear to be reduced volume/fewer neurons in the brainstem and cerebellum, but increased volume in regions of the cerebral cortex (Piven et al., 1996; Carper and Courchesne, 2000). Based on our previous morphological studies, we hypothesize that in subjects with ASD, the SOC occupies significantly less brain volume but also that the constituent nuclei are abnormally arranged and oriented in the brainstem.
This research was supported in part by a March of Dimes Clinical Research Grant (J.P.) and NIMH grants MH51217 (J.P.), MH01028 (J.P.), MH40856 (N.A.), and MH43271 (N.A.). The authors acknowledge the helpful comments of Robert Robinson, M.D., in the preparation of this manuscript.