Absolute quantification methods in tissue near-infrared spectroscopy

Steven J. Matcher; Peter J. Kirkpatrick; K. Nahid; Mark Cope; David T. Delpy

doi:10.1117/12.209997

30 May 1995 Absolute quantification methods in tissue near-infrared spectroscopy

Steven J. Matcher, Peter J. Kirkpatrick, K. Nahid, Mark Cope, David T. Delpy

Proceedings Volume 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation; (1995) https://doi.org/10.1117/12.209997
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Recent work aimed at providing an absolute measurement of tissue haemoglobin saturation and a new instrument development, the spatially resolved spectrometer (SRS), are discussed. The theoretical basis of operation of this device and its hardware implementation are described and the results of validation studies on tissue simulating phantoms are presented as are preliminary measurements on human volunteers and observations on patients undergoing neurosurgery. In its present form the instrument appears to produce absolute haemoglobin saturation values for resting human skeletal muscle and the normally perfused human head which are rather low based on physiological expectations. However, we obtained a tight correlation between the saturation values measured by the SRS instrument and those obtained from blood-gas analysis of samples drawn from a jugular bulb catheter in one neurosurgery subject during clamping of the right carotid arteries.

Citation Download Citation

Steven J. Matcher, Peter J. Kirkpatrick, K. Nahid, Mark Cope, and David T. Delpy "Absolute quantification methods in tissue near-infrared spectroscopy", Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, (30 May 1995); https://doi.org/10.1117/12.209997

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