No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease

M Baker; D Graff-Radford; F Wavrant DeVrièze; N Graff-Radford; R C Petersen; E Kokmen; B Boeve; L Myllykangas; T Polvikoski; R Sulkava; A Verkoniemmi; P Tienari; M Haltia; J Hardy; M Hutton; J Perez-Tur

doi:10.1016/s0304-3940(00)01057-0

No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease

Neurosci Lett. 2000 May 12;285(2):147-9. doi: 10.1016/s0304-3940(00)01057-0.

Authors

M Baker¹, D Graff-Radford, F Wavrant DeVrièze, N Graff-Radford, R C Petersen, E Kokmen, B Boeve, L Myllykangas, T Polvikoski, R Sulkava, A Verkoniemmi, P Tienari, M Haltia, J Hardy, M Hutton, J Perez-Tur

Affiliation

¹ Neurogenetics Laboratories and Neurology Department, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.

PMID: 10793248
DOI: 10.1016/s0304-3940(00)01057-0

Abstract

We and others have previously identified two distinct haplotypes of the TAU gene in Caucasian populations. In this study, we have assessed whether these haplotypes show an association with Alzheimer's disease in a variety of populations. They do not. These data are consistent with the view that the involvement of TAU in Alzheimer's disease is a downstream event.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Age of Onset
Aged
Aged, 80 and over
Alzheimer Disease / epidemiology
Alzheimer Disease / genetics*
Alzheimer Disease / pathology
Genetic Predisposition to Disease*
Haplotypes / genetics*
Humans
Population Surveillance*
Supranuclear Palsy, Progressive / epidemiology
Supranuclear Palsy, Progressive / genetics
Supranuclear Palsy, Progressive / pathology
tau Proteins / genetics*

Substances

tau Proteins