Chronic parvovirus B-19 meningoencephalitis with additional detection of Epstein-Barr virus DNA in the cerebrospinal fluid of an immunocompetent patient

J Neurovirol. 2000 Oct;6(5):418-22. doi: 10.3109/13550280009018306.

Abstract

Parvovirus B19 DNA was detected by polymerase chain reaction in the brain biopsy specimen from a 67-year-old immunocompetent woman with severe chronic lymphocytic meningoencephalitis. In addition to parvovirus B19, Epstein-Barr virus DNA was identified in the CSF. Genomic material from Epstein-Barr virus was absent in the brain tissue. Clinical symptoms and CSF pleocytosis improved under long-term corticosteroid-treatment. The aetio-pathogenetic role of parvovirus B19 and the possible meaning of the additionally detected Epstein-Barr virus DNA are discussed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biopsy
  • Brain / pathology
  • Brain / virology
  • Chronic Disease
  • DNA, Viral / cerebrospinal fluid
  • Encephalitis, Viral / diagnosis*
  • Encephalitis, Viral / pathology
  • Encephalitis, Viral / virology
  • Epstein-Barr Virus Infections / diagnosis*
  • Epstein-Barr Virus Infections / immunology
  • Epstein-Barr Virus Infections / virology
  • Female
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / isolation & purification*
  • Humans
  • Immunocompetence*
  • Meningitis, Viral / diagnosis*
  • Meningitis, Viral / pathology
  • Meningitis, Viral / virology
  • Parvoviridae Infections / diagnosis*
  • Parvoviridae Infections / immunology
  • Parvovirus B19, Human / isolation & purification*

Substances

  • DNA, Viral