Abstract
Supplementation or deficiency of nicotinamide in rats may interfere with the oxidative balance, with excess leading to greater lipid peroxidation, measured by TBARS, and deficiency causing a greater consumption of antioxidants such as vitamin E and glutathione. Urinary N-methylnicotinamide excretion was much more marked in the supplemented group, whereas the difference between deficient and control animals was nonsignificant.
MeSH terms
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Animals
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Antioxidants / metabolism
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Dietary Supplements
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Glutathione / metabolism
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Lipid Peroxidation / drug effects
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Lipid Peroxidation / physiology*
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Liver / drug effects
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Liver / metabolism*
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Male
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NAD
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Niacinamide / analogs & derivatives
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Niacinamide / deficiency*
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Niacinamide / metabolism
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Niacinamide / pharmacology*
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Niacinamide / urine
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Oxidation-Reduction
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Rats
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Rats, Wistar
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Thiobarbituric Acid Reactive Substances
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Vitamin E / metabolism
Substances
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Antioxidants
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Thiobarbituric Acid Reactive Substances
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NAD
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Vitamin E
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Niacinamide
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Glutathione
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N-methylnicotinamide