IgG monoclonal proteins from patients with axonal peripheral neuropathies bind to different epitopes of the 68 kDa neurofilament protein

R Fazio; R Nemni; A Quattrini; I Lorenzetti; N Canal

doi:10.1016/0165-5728(92)90041-i

IgG monoclonal proteins from patients with axonal peripheral neuropathies bind to different epitopes of the 68 kDa neurofilament protein

J Neuroimmunol. 1992 Feb;36(2-3):97-104. doi: 10.1016/0165-5728(92)90041-i.

Authors

R Fazio¹, R Nemni, A Quattrini, I Lorenzetti, N Canal

Affiliation

¹ Department of Neurology, University of Milan, Italy.

PMID: 1370672
DOI: 10.1016/0165-5728(92)90041-i

Abstract

We describe three patients with a sensorimotor axonal polyneuropathy and an IgG M-protein that binds to a 68 kDa axonal protein identified as the low molecular weight neurofilament protein (NF-L). The immunological studies revealed that the M-proteins have different target epitopes: one is phosphorylated and the other two are nonphosphorylated. One of the nonphosphorylated epitopes is common to other intermediate filaments, such as desmin and vimentin.

Publication types

Case Reports

MeSH terms

Axons / immunology*
Blood Proteins / immunology*
Epitopes / immunology*
Humans
Immunoglobulin G / analysis
Immunoglobulin G / immunology*
Immunoglobulins*
Immunohistochemistry
Male
Middle Aged
Neurofilament Proteins / immunology*
Peripheral Nervous System Diseases / immunology*
Peripheral Nervous System Diseases / pathology
Phosphorylation

Substances

Blood Proteins
Epitopes
Immunoglobulin G
Immunoglobulins
M-proteins (Myeloma)
Neurofilament Proteins