Abstract
Neurotransmitter transporter genes encode proteins with 12 putative transmembrane regions, which mediate Na(+)-dependent reaccumulation of released neurotransmitters into presynaptic terminals and are the sites of action of important abused and therapeutic drugs. Studies of these genes show promise for improving our understanding of transport mechanisms and modes of drug action, and may even uncover previously unanticipated neurotransmitters.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Biological Transport, Active
-
Biomarkers
-
Brain Chemistry
-
Carrier Proteins / genetics
-
Carrier Proteins / metabolism*
-
DNA / genetics
-
Diffusion
-
Dopamine Plasma Membrane Transport Proteins
-
GABA Plasma Membrane Transport Proteins
-
Humans
-
Membrane Glycoproteins / genetics
-
Membrane Glycoproteins / metabolism*
-
Membrane Proteins*
-
Membrane Transport Proteins*
-
Molecular Sequence Data
-
Multigene Family*
-
Nerve Tissue Proteins / genetics
-
Nerve Tissue Proteins / metabolism*
-
Neurons / metabolism*
-
Neurotransmitter Agents / metabolism*
-
Norepinephrine Plasma Membrane Transport Proteins
-
Organic Anion Transporters*
-
Protein Conformation
-
Recombinant Fusion Proteins / metabolism
-
Serotonin Plasma Membrane Transport Proteins
-
Sodium / metabolism
-
Structure-Activity Relationship
-
Symporters*
-
Synaptic Transmission
Substances
-
Biomarkers
-
Carrier Proteins
-
Dopamine Plasma Membrane Transport Proteins
-
GABA Plasma Membrane Transport Proteins
-
Membrane Glycoproteins
-
Membrane Proteins
-
Membrane Transport Proteins
-
Nerve Tissue Proteins
-
Neurotransmitter Agents
-
Norepinephrine Plasma Membrane Transport Proteins
-
Organic Anion Transporters
-
Recombinant Fusion Proteins
-
SLC6A2 protein, human
-
SLC6A4 protein, human
-
Serotonin Plasma Membrane Transport Proteins
-
Symporters
-
DNA
-
Sodium