Abstract
Two novel mutations recently have been identified in the DJ-1 gene that cause a new form of autosomal recessive, early-onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Aged, 80 and over
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Animals
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Brain / metabolism
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Brain / pathology*
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COS Cells
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Chlorocebus aethiops
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Dementia / metabolism
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Dementia / pathology*
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HeLa Cells
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Humans
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Immunoblotting
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Immunohistochemistry
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Inclusion Bodies / metabolism*
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Inclusion Bodies / ultrastructure
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Intracellular Signaling Peptides and Proteins
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Middle Aged
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Neurofibrillary Tangles / metabolism
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Neurofibrillary Tangles / pathology
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Oncogene Proteins / genetics
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Oncogene Proteins / metabolism*
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Parkinsonian Disorders / metabolism
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Parkinsonian Disorders / pathology*
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Protein Deglycase DJ-1
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Transfection
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tau Proteins / metabolism*
Substances
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Intracellular Signaling Peptides and Proteins
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Oncogene Proteins
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tau Proteins
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PARK7 protein, human
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Protein Deglycase DJ-1