Abstract
A case of an infantile type III glycogenosis (Forbes disease), confirmed by morphologic and biochemical studies, had light-microscopic, histochemical, and electron-microscopic evidence of multicore structures and type 1 fiber predominance with hypotrophy. This association is discussed with relation to the unusual clinical findings. The authors conclude that two distinct disease entities--Forbes disease and multicore myopathy--may coexist.
MeSH terms
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Adenosine Triphosphatases / analysis
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Child, Preschool
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Female
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Glycogen / analysis
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Glycogen Storage Disease / pathology*
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Glycogen Storage Disease Type III / metabolism
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Glycogen Storage Disease Type III / pathology*
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Histocytochemistry
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Humans
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Liver / analysis
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Liver / pathology*
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Liver / ultrastructure
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Microscopy, Electron
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Muscles / analysis
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Muscles / pathology*
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Muscles / ultrastructure
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NADH Tetrazolium Reductase / analysis
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Succinate Dehydrogenase / analysis
Substances
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Glycogen
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Succinate Dehydrogenase
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NADH Tetrazolium Reductase
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Adenosine Triphosphatases