Striatal FP-CIT uptake differs in the subtypes of early Parkinson's disease

J Neural Transm (Vienna). 2007 Mar;114(3):331-5. doi: 10.1007/s00702-006-0518-2. Epub 2006 May 24.

Abstract

In idiopathic Parkinson's disease (PD), a tremor-dominant type (TDT), an akinetic-rigid type (ART), and a mixed type (MT) are distinguished. We compared cerebral [I-123]FP-CIT SPECT in the PD subtypes (67 patients Hoehn and Yahr stage 1:26 with ART, 19 with MT, 22 with TDT). We measured the ratios putamen/occipital lobe binding and caudate nucleus/occipital lobe binding. Parkinsonian motor symptoms were quantified by UPDRS motor scale. In both putamen and caudate nucleus contralateral to the clinically affected body side TDT patients showed a significantly higher FP-CIT uptake than ART or MT patients (ANOVA; p<0.01). Contralateral putamen and caudate nucleus FP-CIT uptake correlated significantly with severity of rigidity (p<0.01) and hypokinesia (p<0.01) but not with severity of resting or postural tremor (p>0.05). The missing correlation between striatal FP-CIT uptake and tremor suggests, that further systems besides the nigrostriatal dopaminergic system may contribute to generation of parkinsonian tremor.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Age of Onset
  • Aged
  • Binding, Competitive / drug effects
  • Caudate Nucleus / diagnostic imaging
  • Caudate Nucleus / metabolism
  • Caudate Nucleus / physiopathology
  • Corpus Striatum / diagnostic imaging*
  • Corpus Striatum / physiopathology
  • Diagnosis, Differential
  • Disease Progression
  • Dopamine / metabolism*
  • Dopamine Plasma Membrane Transport Proteins / metabolism*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle Rigidity / diagnostic imaging
  • Muscle Rigidity / metabolism
  • Muscle Rigidity / physiopathology
  • Occipital Lobe / diagnostic imaging
  • Occipital Lobe / metabolism
  • Occipital Lobe / physiopathology
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / diagnostic imaging*
  • Parkinson Disease / physiopathology
  • Predictive Value of Tests
  • Putamen / diagnostic imaging
  • Putamen / metabolism
  • Putamen / physiopathology
  • Substantia Nigra / metabolism
  • Substantia Nigra / physiopathology
  • Tomography, Emission-Computed, Single-Photon / methods
  • Tremor / diagnostic imaging
  • Tremor / metabolism
  • Tremor / physiopathology
  • Tropanes* / pharmacokinetics

Substances

  • Dopamine Plasma Membrane Transport Proteins
  • Tropanes
  • 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
  • Dopamine