Abstract
The inside-out patch clamp technique was used to record the effects of K+ channel openers (EMD 52692, RP 49356 and Cromakalim) on single channel currents in membrane blebs of human skeletal muscle. Two types of K+ channels were activated by these drugs: an ATP-sensitive K+ channel which was inhibited by 3 mM ATP and 5 microM Glibenclamide and an ATP insensitive K+ channel. The open probability of both types was strongly increased by K+ channel openers. Glibenclamide antagonized the action of the K+ channel openers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / pharmacology
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Benzopyrans / pharmacology*
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Cromakalim
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Dihydropyridines / pharmacology*
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Electrophysiology
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Glyburide / pharmacology
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Humans
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Muscles / metabolism*
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Picolines / pharmacology*
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Potassium Channels / drug effects
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Potassium Channels / metabolism*
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Potassium Channels / physiology
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Pyrans / pharmacology*
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Pyrroles / pharmacology*
Substances
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Benzopyrans
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Dihydropyridines
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Picolines
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Potassium Channels
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Pyrans
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Pyrroles
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Cromakalim
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aprikalim
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bimakalim
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Adenosine Triphosphate
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Glyburide