Two different types of potassium channels in human skeletal muscle activated by potassium channel openers

Neurosci Lett. 1990 Nov 13;119(2):191-4. doi: 10.1016/0304-3940(90)90831-s.

Abstract

The inside-out patch clamp technique was used to record the effects of K+ channel openers (EMD 52692, RP 49356 and Cromakalim) on single channel currents in membrane blebs of human skeletal muscle. Two types of K+ channels were activated by these drugs: an ATP-sensitive K+ channel which was inhibited by 3 mM ATP and 5 microM Glibenclamide and an ATP insensitive K+ channel. The open probability of both types was strongly increased by K+ channel openers. Glibenclamide antagonized the action of the K+ channel openers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / pharmacology
  • Benzopyrans / pharmacology*
  • Cromakalim
  • Dihydropyridines / pharmacology*
  • Electrophysiology
  • Glyburide / pharmacology
  • Humans
  • Muscles / metabolism*
  • Picolines / pharmacology*
  • Potassium Channels / drug effects
  • Potassium Channels / metabolism*
  • Potassium Channels / physiology
  • Pyrans / pharmacology*
  • Pyrroles / pharmacology*

Substances

  • Benzopyrans
  • Dihydropyridines
  • Picolines
  • Potassium Channels
  • Pyrans
  • Pyrroles
  • Cromakalim
  • aprikalim
  • bimakalim
  • Adenosine Triphosphate
  • Glyburide