Executive dysfunction is the primary cognitive impairment in progressive supranuclear palsy

Arch Clin Neuropsychol. 2013 Mar;28(2):104-13. doi: 10.1093/arclin/acs098. Epub 2012 Nov 4.

Abstract

Cognitive difficulties appear to be a more prevalent clinical feature in progressive supranuclear palsy (PSP) than previously thought, and significant cognitive impairment is prevalent in a majority of patients PSP patients not considered clinically demented. The neurocognitive performance of 200 patients with PSP across multiple sites was examined with a variety of commonly used neuropsychological tests. Results indicate primary executive dysfunction (e.g., 74% impaired on the Frontal Assessment Battery, 55% impaired on Initiation/Perseveration subscale of the Dementia Rating Scale), with milder difficulties in memory, construction, and naming. These results have important clinical implications for providers following patients with PSP.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cognition Disorders / etiology*
  • Cognition Disorders / psychology
  • Executive Function*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Supranuclear Palsy, Progressive / complications*
  • Supranuclear Palsy, Progressive / psychology
  • Verbal Learning