Abstract
In vitro cultured murine Schwann cells which were devoid of class I and class II gene products of the major histocompatibility complex expressed class I, though not class II, antigens after stimulation with recombinant interferon-gamma. Recombinant IFN-gamma-stimulated Schwann cells after priming with M. leprae were lysed by antigen-specific CD8+ T lymphocytes in vitro. These findings suggest that specific lysis of M. leprae-infected Schwann cells by CD8+ CTL plays a role in leprosy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Bacterial / analysis*
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Antigens, Bacterial / immunology
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Antigens, Differentiation, T-Lymphocyte* / immunology
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Cells, Cultured
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Cytotoxicity, Immunologic*
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Epitopes / immunology
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Mice
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Mice, Inbred C57BL
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Mycobacterium leprae / immunology*
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Phenotype
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Schwann Cells / immunology*
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T-Lymphocytes, Cytotoxic / classification*
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T-Lymphocytes, Cytotoxic / immunology
Substances
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Antigens, Bacterial
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Antigens, Differentiation, T-Lymphocyte
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Epitopes