Abstract
Immunoblotting studies on mitochondria prepared from the striata of patients who died of Parkinson's disease were performed using specific antisera against Complexes I, III and IV. In 4 out of 5 patients with Parkinson's disease, the 30-, 25- and 24-kDa subunits of Complex I were moderately to markedly decreased. No clear difference was noted in immunoblotting studies on subunits of Complexes III and IV between the control and Parkinson's disease. Deficiencies in Complex I subunits seem to be one of the most important clues to elucidate pathogenesis of Parkinson's disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Corpus Striatum / enzymology*
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Electron Transport Complex III / isolation & purification
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Electron Transport Complex IV / isolation & purification
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Humans
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Immunoblotting
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Macromolecular Substances
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Mitochondria / enzymology*
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NAD(P)H Dehydrogenase (Quinone)
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Oxygen Consumption
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Parkinson Disease / enzymology*
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Quinone Reductases / deficiency*
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Quinone Reductases / isolation & purification
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Quinone Reductases / metabolism
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Reference Values
Substances
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Macromolecular Substances
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NAD(P)H Dehydrogenase (Quinone)
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Quinone Reductases
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Electron Transport Complex IV
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Electron Transport Complex III