Diagnosis of cerebral Whipple's disease by cerebrospinal fluid cytology

Arch Psychiatr Nervenkr (1970). 1982;231(3):283-7. doi: 10.1007/BF00343298.

Abstract

In a case of Whipple's disease the diagnosis was made by careful cytologic evaluation of the cerebrospinal fluid (CSF), identifying "Sieracki cells". A basal granuloma invaded the hypothalamus, diencephalon, and rostral parts of the brainstem. An exploration in the initial stage led to misdiagnosis as a granular cell tumor. Diagnosis was then confirmed by intestinal biopsy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Diseases / cerebrospinal fluid*
  • Brain Diseases / diagnosis
  • Brain Diseases / etiology
  • Humans
  • Immunoglobulin A / metabolism
  • Lysosomes / enzymology
  • Male
  • Mitogens
  • Whipple Disease / cerebrospinal fluid*
  • Whipple Disease / complications
  • Whipple Disease / diagnosis
  • Whipple Disease / therapy

Substances

  • Immunoglobulin A
  • Mitogens