Abstract
We studied the effect of acetazolamide on arterial-venous (A-V) glucose and potassium differences across the forearm following oral glucose loading in eight normal subjects. Administration of acetazolamide for 72 hours prior to glucose loading resulted in increased A-V glucose differences and decreased A-V potassium differences. Acetazolamide may, therefore, increase glucose uptake across muscle while decreasing potassium uptake following glucose ingestion. This glucose-potassium dissociation observed in normal subjects may relate to acetazolamide's beneficial effect in hypokalemic periodic paralysis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetazolamide / pharmacology*
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Acetazolamide / therapeutic use
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Adult
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Blood Glucose / analysis*
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Blood Glucose / metabolism
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Cell Membrane / metabolism
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Dietary Carbohydrates / metabolism
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Female
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Forearm / blood supply
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Humans
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Hypokalemia / blood
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Hypokalemia / drug therapy
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Hypokalemia / metabolism
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Male
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Muscles / metabolism
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Paralyses, Familial Periodic / blood*
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Paralyses, Familial Periodic / drug therapy
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Paralyses, Familial Periodic / metabolism
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Potassium / blood*
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Potassium / metabolism
Substances
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Blood Glucose
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Dietary Carbohydrates
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Acetazolamide
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Potassium