Downbeat nystagmus due to anticonvulsant toxicity

Ann Neurol. 1978 Nov;4(5):471-3. doi: 10.1002/ana.410040516.

Abstract

Isolated downbeat nystagmus was observed in 2 patients on multiple anticonvulsant regimens. The nystagmus disappeared when phenytoin dosage was reduced. Electrooculographic analysis revealed impaired downward tracking, supporting the concept of "pursuit" nystagmus.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticonvulsants / adverse effects*
  • Carbamazepine / adverse effects
  • Eye Movements
  • Female
  • Humans
  • Nystagmus, Pathologic / chemically induced*
  • Nystagmus, Pathologic / physiopathology
  • Phenytoin / adverse effects
  • Primidone / adverse effects

Substances

  • Anticonvulsants
  • Primidone
  • Carbamazepine
  • Phenytoin