Abstract
We present four patients--two pairs of siblings--followed for many years, with pyramidal and parkinsonian features, who responded consistently to levodopa therapy. The patients belong to two unrelated consanguineous families, suggesting that this condition is genetically determined and recessively inherited.
MeSH terms
-
Adolescent
-
Adult
-
Basal Ganglia Diseases / drug therapy
-
Basal Ganglia Diseases / genetics*
-
Carbidopa / adverse effects
-
Carbidopa / therapeutic use
-
Child
-
Dose-Response Relationship, Drug
-
Drug Administration Schedule
-
Female
-
Follow-Up Studies
-
Humans
-
Levodopa / adverse effects
-
Levodopa / therapeutic use*
-
Male
-
Neurologic Examination / drug effects
-
Parkinson Disease / drug therapy
-
Parkinson Disease / genetics*
-
Pedigree