Abstract
SPECT with the benzodiazepine receptor antagonist 123I-Iomazenil was performed in 33 patients with intractable partial seizures for pre-operative evaluation. The results combined with MRI and 99mTc-HMPAO-SPECT findings were compared with the video-assisted EEG monitoring ("gold standard") which localised the focus in 25 patients. 11 patients underwent surgical resection of the epileptogenic area and became seizure-free for a period up to 13 months. The Iomazenil SPECT had a significantly higher sensitivity compared to 99mTc-HMPAO in the visualization of an epileptogenic area and should be regularly used in the diagnostic of medically intractable partial seizures.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Brain / diagnostic imaging*
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Child
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Electroencephalography*
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Epilepsies, Partial / diagnostic imaging*
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Epilepsies, Partial / physiopathology
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Epilepsies, Partial / surgery
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Female
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Flumazenil / analogs & derivatives*
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Follow-Up Studies
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Humans
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Iodine Radioisotopes
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Male
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Middle Aged
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Monitoring, Physiologic
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Organotechnetium Compounds
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Oximes
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Postoperative Period
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Predictive Value of Tests
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Technetium Tc 99m Exametazime
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Time Factors
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Tomography, Emission-Computed, Single-Photon*
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Video Recording
Substances
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Iodine Radioisotopes
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Organotechnetium Compounds
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Oximes
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Technetium Tc 99m Exametazime
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Flumazenil
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iomazenil