Abstract
The authors review the relationship of repetitive behaviors to frontal lobe degenerations and report the repetitive and compulsive behaviors, radiologic imaging findings, and neuropathology of 3 patients with dementia secondary to frontal lobe degeneration. These 3 patients and 78% of 46 proven pathologic cases of frontal lobe degeneration described in the literature demonstrate repetitive behaviors ranging from motor stereotypies to complex obsessive-compulsive disorder. This review suggests that combined damage to the frontal lobe, caudate nucleus, and globus pallidus may account for the repetitive behaviors seen in frontal lobe degenerations, idiopathic obsessive-compulsive disorder, and other neuropsychiatric diseases.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Brain Mapping
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Caudate Nucleus / pathology
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Caudate Nucleus / physiopathology
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Compulsive Behavior / diagnosis
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Compulsive Behavior / pathology
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Compulsive Behavior / physiopathology*
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Dementia / diagnosis
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Dementia / pathology
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Dementia / physiopathology
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Female
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Frontal Lobe / pathology
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Frontal Lobe / physiopathology*
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Globus Pallidus / pathology
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Globus Pallidus / physiopathology
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Humans
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Male
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Middle Aged
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Nerve Degeneration / physiology*
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Neurocognitive Disorders / diagnosis
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Neurocognitive Disorders / pathology
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Neurocognitive Disorders / physiopathology*
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Obsessive-Compulsive Disorder / diagnosis
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Obsessive-Compulsive Disorder / pathology
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Obsessive-Compulsive Disorder / physiopathology*
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Recurrence
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Stereotyped Behavior / physiology
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Tomography, Emission-Computed
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Tomography, Emission-Computed, Single-Photon