Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease

J Neuropathol Exp Neurol. 1994 Sep;53(5):429-37. doi: 10.1097/00005072-199409000-00002.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / physiopathology
  • Amyloid / physiology
  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Protein Precursor / genetics
  • Apolipoproteins E / genetics*
  • Apolipoproteins E / physiology*
  • Genotype
  • Humans
  • Isomerism
  • Models, Neurological
  • Mutation
  • Time Factors

Substances

  • Amyloid
  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Apolipoproteins E