Abstract
Two major sources of dissatisfaction with the quality of life among Parkinsonian patients are the "locomotor disability" and the "nature of their sleep". The main focus of research was directed towards the locomotor disability, but in the last two decades some progress has been made towards the understanding of sleep in PD patients. Sleep in Parkinson's disease is light and fragmented due to an increased skeletal muscle activity, disturbed breathing, impaired biological rhythm and REM-nonREM variations of the dopaminergic receptor sensitivity.
MeSH terms
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Antiparkinson Agents / adverse effects
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Antiparkinson Agents / therapeutic use
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Biological Clocks / drug effects
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Biological Clocks / physiology
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Humans
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Hypnotics and Sedatives / adverse effects
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Hypnotics and Sedatives / therapeutic use
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Muscle Contraction / drug effects
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Muscle Contraction / physiology
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Parkinson Disease / drug therapy
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Parkinson Disease / physiopathology*
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Sleep Initiation and Maintenance Disorders / drug therapy
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Sleep Initiation and Maintenance Disorders / physiopathology
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Sleep Stages / drug effects
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Sleep Stages / physiology*
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Sleep, REM / drug effects
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Sleep, REM / physiology
Substances
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Antiparkinson Agents
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Hypnotics and Sedatives