During spinal surgery, motor evoked potentials (MEPs) were recorded from distal upper and lower limb muscles following multipulse transcranial electrical stimulation of the cortex. Twenty-two patients, 9 of them myelopathic, were anaesthetised with propofol +/- nitrous oxide. Using trains of 3-6 pulses separated by 2 ms, consistent responses generally measuring more than 100 microV were obtained from every patient except one, and persisted with nitrous oxide concentrations as high as 74%. Responses could usually be elicited from 3 or more limbs simultaneously, although the location of the stimulating anode was sometimes critical. The lower limb responses of one patient disappeared transiently during excision of an intramedullary tumour; his leg weakness was increased for a few days after surgery. Three other patients experienced increased weakness or spasticity, two without concomitant MEP changes and one with no recordable responses. Although other methods may be preferable in some circumstances, we believe this represents an advance over previously reported non-invasive techniques for peroperative MEP monitoring, and may be particularly useful for monitoring patients with myelopathy in the thoracic region.