Abstract
The authors examined the clinical and neuropathological characteristics of a patient who developed features of obsessive-compulsive disorder (OCD) and anorexia nervosa (AN) as the initial presentation of Creutzfeldt-Jakob disease. He had mild Parkinsonism and showed deficits in visual scanning, set shifting, graphomotor speed, sequencing, and verbal and nonverbal memory. Neuropathological study showed spongiosis and neuronal loss in cortical (e.g., frontal, temporal, parietal), and especially in subcortical structures (e.g., basal ganglia, thalamus). This study supports the hypothesis of abnormal frontal-striatal functioning in the cause of OCD, even in demented subjects. In addition, the authors discuss the role of frontal-temporal-subcortical dysfunction in the cause of acquired AN.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Anorexia Nervosa / diagnosis
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Anorexia Nervosa / physiopathology*
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Anorexia Nervosa / psychology
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Brain / pathology
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Brain / physiopathology*
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Brain Mapping
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Cerebral Cortex / pathology
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Cerebral Cortex / physiopathology*
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Creutzfeldt-Jakob Syndrome / diagnosis
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Creutzfeldt-Jakob Syndrome / physiopathology*
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Creutzfeldt-Jakob Syndrome / psychology
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Diagnosis, Differential
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Humans
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Male
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Neurocognitive Disorders / diagnosis
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Neurocognitive Disorders / physiopathology*
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Neurocognitive Disorders / psychology
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Neurologic Examination
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Neuropsychological Tests
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Obsessive-Compulsive Disorder / diagnosis
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Obsessive-Compulsive Disorder / physiopathology*
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Obsessive-Compulsive Disorder / psychology
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Parkinson Disease, Secondary / diagnosis
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Parkinson Disease, Secondary / physiopathology
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Parkinson Disease, Secondary / psychology