Symptoms of spinal stenosis do not improve after epidural steroid injection

Clin J Pain. 1998 Jun;14(2):148-51. doi: 10.1097/00002508-199806000-00010.

Abstract

Objective: This study was carried out to evaluate the therapeutic effect of epidural steroid injection on pseudoclaudication in patients with lumbar degenerative spinal canal stenosis.

Design: Fifty-three patients who complained of pseudoclaudication of less than 20 m in walking distance were randomly divided into three groups. Group 1 (n = 16) underwent epidural injection with 8 ml of saline. Group 2 (n = 18) underwent epidural block with 8 ml of 1% mepivacaine. Group 3 (n = 19) underwent epidural block with a combination of 8 ml of 1% mepivacaine and 40 mg of methylprednisolone. The criteria of evaluation were as follows: excellent effect, > 100 m in walking distance; good effect, 20-100 m in walking distance; poor effect, <20 m in walking distance.

Results: In group 1, the numbers of patients who showed a good effect were two (12.5%) after 1 week, one (6.5%) after 1 month, and one (6.5%) after 3 months. In group 2, the numbers of patients who showed a good or excellent result were 10 (55.5%) after 1 week, three (16.7%) after 1 month, and one (5.6%) after 3 months. In group 3, the numbers of patients who showed a good or excellent result were 12 (63.2%) after 1 week, three (15.8%) after 1 month, and one (5.3%) after 3 months. There was no significant difference in the effectiveness of treatment between group 2 and group 3 throughout the time course.

Conclusion: The results suggest that epidural steroid injection has no beneficial effect on the pseudoclaudication associated with spinal canal stenosis as compared with epidural block with a local anesthetic alone.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Analgesia, Epidural
  • Anesthetics, Local / therapeutic use*
  • Anti-Inflammatory Agents / therapeutic use*
  • Drug Combinations
  • Female
  • Humans
  • Injections, Epidural
  • Intermittent Claudication / drug therapy*
  • Intermittent Claudication / etiology*
  • Lumbosacral Region
  • Male
  • Mepivacaine / therapeutic use
  • Methylprednisolone / therapeutic use*
  • Nerve Block
  • Spinal Stenosis / complications*
  • Treatment Failure

Substances

  • Anesthetics, Local
  • Anti-Inflammatory Agents
  • Drug Combinations
  • Mepivacaine
  • Methylprednisolone