Heat shock proteins (Hsps) have been studied for many years and there is now a large body
of evidence that demonstrates the role of Hsp upregulation in tissue and cell protection in a …

The distal hereditary motor neuropathies (dHMN) comprise a heterogenous group of
diseases that share the common feature of a length-dependent predominantly motor …

Arimoclomol is a hydroxylamine derivative, a group of compounds which have unique
properties as co-inducers of heat shock protein expression, but only under conditions of …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition in which
motoneurons of the spinal cord and motor cortex die, resulting in progressive paralysis,. This …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder
characterized by motoneuron degeneration, resulting in muscle paralysis and death …

TDP‐43 (encoded by the gene TARDBP) is an RNA binding protein central to the
pathogenesis of amyotrophic lateral sclerosis (ALS). However, how TARDBP mutations …

Mutations in FUS are causative for amyotrophic lateral sclerosis with a dominant mode of
inheritance. In trying to model FUS-amyotrophic lateral sclerosis (ALS) in mouse it is clear …

Sporadic inclusion body myositis (sIBM) is the commonest severe myopathy in patients more
than 50 years of age. Previous therapeutic trials have targeted the inflammatory features of …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that results
in the death of motor neurons in the brain and spinal cord. The disorder generally strikes in …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the
degeneration of upper and lower motor neurons. Defects in axonal transport have been …