Importance Individuals in the presymptomatic stage of Alzheimer disease (AD) are
increasingly being targeted for AD secondary prevention trials. How early during the normal …

Failures in Alzheimer's disease (AD) drug trials highlight the need to further explore disease
mechanisms and alterations of biomarkers during the development of AD. Using cross …

The core cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers amyloid beta (Aβ42
and Aβ40), total tau, and phosphorylated tau, have been extensively clinically validated, with …

Objective Phosphorylated neurofilament heavy chain (pNfH) levels are elevated in
cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). Instead of …

Astrocytes exhibit a prominent glycolytic activity, but whether such a metabolic profile is
influenced by intercellular communication is unknown. Treatment of primary cultures of …

Introduction Reference materials based on human cerebrospinal fluid were certified for the
mass concentration of amyloid beta (Aβ) 1‐42 (Aβ42). They are intended to be used to …

Introduction We aimed to investigate factors defining amyloid β (1–42)(Aβ 1–42) adsorption
during preanalytical workup of cerebrospinal fluid (CSF). Methods CSF was transferred to …

Background: Reduced cerebrospinal fluid (CSF) concentration of amyloid-β 1-42 (Aβ 1-42)
reflects the presence of amyloidopathy in brains of subjects with Alzheimer's disease (AD) …

Introduction The aim was to create readily available algorithms that estimate the individual
risk of β-amyloid (Aβ) positivity. Methods The algorithms were tested in BioFINDER (n= 391 …

Hypoxia-inducible factors (HIFs) regulate more than 200 genes involved in cellular
adaptation to reduced oxygen availability. HIFs are heterodimeric transcription factors that …