Background It is widely believed that females have longer telomeres than males, although
results from studies have been contradictory. Methods We carried out a systematic review …

Ageing is a multifactorial process associated with reduced function and increased risk of
morbidity and mortality. Recently, nine cellular and molecular hallmarks of ageing have …

Loss of cortical nicotinic acetylcholine receptors with high affinity for agonists (20–50%) in
patients with Alzheimer's disease is a common finding. Recent immunochemical analyses …

The impact of cellular senescence onto aging of organisms is not fully clear, not at least
because of the scarcity of reliable data on the mere frequency of senescent cells in aging …

Senescent cells produce and secrete various bioactive molecules including interleukins,
growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has …

Objectives The Newcastle 85+ Study aims to systematically study the clinical, biological, and
psychosocial attributes of an unselected cohort of 85 year olds and to examine subsequent …

Age-related frailty is an increasing societal challenge with growing emphasis on identifying
its underlying pathophysiology and prospects for intervention. We report findings from the …

Cross‐sectional studies have repeatedly suggested peripheral blood monocyte telomere
length as a biomarker of aging. To test this suggestion in a large population‐based follow …

OBJECTIVE: Measures of cholinergic transmitter activity were investigated in patients with
autism because of reported neuropathological abnormalities in cholinergic nuclei in the …

To determine the most important drivers of successful ageing at extreme old age, we
combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health …