The human prion diseases comprise Creutzfeldt–Jakob disease, variably protease-sensitive
prionopathy, Gerstmann–Sträussler–Scheinker disease, fatal familial insomnia, and kuru …

The immune system is central in the pathogenesis of scrapie and other transmissible
spongiform encephalopathies (TSEs) or'prion'diseases 1. After infecting by peripheral …

Twenty-five years has now passed since variant Creutzfeldt-Jakob disease (vCJD) was first
described in the United Kingdom (UK). Early epidemiological, neuropathological and …

Variably protease-sensitive prionopathy is a newly described human prion disease of
unknown aetiology lying out with the hitherto recognized phenotypic spectrum of Creutzfeldt …

Objective To perform prion protein gene (PRNP) codon 129 analysis in DNA extracted from
appendix tissue samples that had tested positive for disease associated prion protein …

Human-to-human transmission of Creutzfeldt–Jakob disease (CJD) has occurred through
medical procedures resulting in iatrogenic CJD (iCJD). One of the commonest causes of …

Objective To establish with improved accuracy the prevalence of disease related prion
protein (PrP CJD) in the population of Britain and thereby guide a proportionate public …

Molecular typing of the abnormal form of the prion protein (PrPSc) has come to be regarded
as a powerful tool in the investigation of the prion diseases. All evidence thus far presented …

Variant Creutzfeldt-Jakob disease (vCJD) differs from other human prion diseases in that the
pathogenic prion protein PrPSc can be detected to a greater extent at extraneuronal sites …

The current classification of sporadic Creutzfeldt–Jakob disease (sCJD) includes six major
clinicopathological subtypes defined by the physicochemical properties of the protease …