Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have
been closely linked to the pathogenesis of several neurodegenerative diseases. Tryptophan …

Protein misfolding and aggregation are central events in many disorders including several
neurodegenerative diseases. This suggests that alterations in normal protein homeostasis …

Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson's disease (PD)
and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions …

Metabolites in the kynurenine pathway, generated by tryptophan degradation, are thought to
play an important role in neurodegenerative disorders, including Alzheimer's and …

Huntington disease is a fatal neurodegenerative disorder caused by expansion of a
polyglutamine tract in the protein huntingtin (Htt), which leads to its aggregation in nuclear …

Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have
been implicated in the pathophysiology of neurodegenerative disorders, including …

α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several
other neurodegenerative diseases known as synucleinopathies. The toxic properties of α …

Parkinson's disease (PD) is a devastating neurodegenerative disorder characterized by the
loss of neurons in the substantia nigra pars compacta and the presence of Lewy bodies in …

Metabolites of the kynurenine pathway (KP) of tryptophan (TRP) degradation have been
closely linked to the pathogenesis of several neurodegenerative disorders. Recent work has …

In Huntington disease (HD), immune cells are activated before symptoms arise; however, it
is unclear how the expression of mutant huntingtin (htt) compromises the normal functions of …