HIV-1 protease inhibitors: a review for clinicians
SG Deeks, M Smith, M Holodniy, JO Kahn - Jama, 1997 - jamanetwork.com
Objective.—The clinical care of people infected with human immunodeficiency virus (HIV)
has been substantially affected by the introduction of HIV-specific protease inhibitors (Pis) …
has been substantially affected by the introduction of HIV-specific protease inhibitors (Pis) …
[HTML][HTML] Oxidative stress in Alzheimer's disease
MA Smith, CA Rottkamp, A Nunomura, AK Raina… - … et Biophysica Acta (BBA …, 2000 - Elsevier
Oxidative balance is emerging as an important issue in understanding the pathogenesis of
Alzheimer's disease. Examination of Alzheimer's disease brain has demonstrated a great …
Alzheimer's disease. Examination of Alzheimer's disease brain has demonstrated a great …
Oxidative stress and neurotoxicity
LM Sayre, G Perry, MA Smith - Chemical research in toxicology, 2008 - ACS Publications
There is increasing awareness of the ubiquitous role of oxidative stress in
neurodegenerative disease states. A continuing challenge is to be able to distinguish …
neurodegenerative disease states. A continuing challenge is to be able to distinguish …
[HTML][HTML] Accurate whole human genome sequencing using reversible terminator chemistry
DR Bentley, S Balasubramanian, HP Swerdlow… - nature, 2008 - nature.com
DNA sequence information underpins genetic research, enabling discoveries of important
biological or medical benefit. Sequencing projects have traditionally used long (400–800 …
biological or medical benefit. Sequencing projects have traditionally used long (400–800 …
Towards a better understanding of context and context-awareness
When humans talk with humans, they are able to use implicit situational information, or
context, to increase the conversational bandwidth. Unfortunately, this ability to convey ideas …
context, to increase the conversational bandwidth. Unfortunately, this ability to convey ideas …
Oxidative damage is the earliest event in Alzheimer disease
Recently, we demonstrated a significant increase of an oxidized nucleoside derived from
RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable …
RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable …
Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
MA Smith, S Makino, R Kvetnansky… - Journal of …, 1995 - Soc Neuroscience
Chronic stress produces structural changes and neuronal damage especially in the
hippocampus. Because neurotrophic factors affect neuron survival, we questioned whether …
hippocampus. Because neurotrophic factors affect neuron survival, we questioned whether …
[BOOK][B] Multinuclear solid-state nuclear magnetic resonance of inorganic materials
KJD MacKenzie, ME Smith - 2002 - books.google.com
Techniques of solid state nuclear magnetic resonance (NMR) spectroscopy are constantly
being extended to a more diverse range of materials, pressing into service an ever …
being extended to a more diverse range of materials, pressing into service an ever …
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
MA Smith, PLR Harris, LM Sayre… - Proceedings of the …, 1997 - National Acad Sciences
Damage from free radicals has been demonstrated in susceptible neuronal populations in
cases of Alzheimer disease. In this study, we investigated whether iron, a potent source of …
cases of Alzheimer disease. In this study, we investigated whether iron, a potent source of …
Mitochondrial abnormalities in Alzheimer's disease
K Hirai, G Aliev, A Nunomura, H Fujioka… - Journal of …, 2001 - Soc Neuroscience
The finding that oxidative damage, including that to nucleic acids, in Alzheimer's disease is
primarily limited to the cytoplasm of susceptible neuronal populations suggests that …
primarily limited to the cytoplasm of susceptible neuronal populations suggests that …