Pancreatic cancer remains one of the most lethal of malignancies and a major health
burden. We performed whole-genome sequencing and copy number variation (CNV) …

Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32
recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH …

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed
exome sequencing and copy number analysis to define genomic aberrations in a …

A number of mutations in the X‐chromosomal human iduronate‐2‐sulphatase gene have
now been identified as the primary genetic defect leading to the clinical condition known as …

Patients with high-grade serous ovarian cancer (HGSC) have experienced little
improvement in overall survival, and standard treatment has not advanced beyond platinum …

The past 20 years have witnessed an explosion in our knowledge of keratoconus,
accompanied by a radical transformation of management options. A 2-hit hypothesis …

A key element of most recently proposed plant strategy schemes is an axis of resource
capture, usage and availability. In the search for a simple, robust plant trait (or traits) that will …

The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …

A long-term research programme, conducted mainly in northern England, has involved field
surveys (1965-77), laboratory screening (1974-96), monitoring of permanent plots (1958 to …

Multiplicative potentials, appropriate for adding to the non-multiplicative fractional orbital
exchange term in the Kohn–Sham equations, are determined from correlated ab initio …