Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation
T Tsuboi, H Watanabe, Y Tanaka, R Ohdake… - Journal of Neurology …, 2015 - jnnp.bmj.com
Objectives To elucidate the phenotypes and pathophysiology of speech and voice disorders
in Parkinson's disease (PD) with subthalamic nucleus deep brain stimulation (STN-DBS) …
in Parkinson's disease (PD) with subthalamic nucleus deep brain stimulation (STN-DBS) …
Analysis of C9orf72 repeat expansion in 563 Japanese patients with amyotrophic lateral sclerosis
K Ogaki, Y Li, N Atsuta, H Tomiyama, M Funayama… - Neurobiology of …, 2012 - Elsevier
Recently, a hexanucleotide repeat expansion in C9orf72 was identified as the most common
cause of both sporadic and familial amyotrophic lateral sclerosis (ALS) and frontotemporal …
cause of both sporadic and familial amyotrophic lateral sclerosis (ALS) and frontotemporal …
Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients
H Watanabe, N Atsuta, R Nakamura… - … Lateral Sclerosis and …, 2015 - Taylor & Francis
Our objective was to elucidate the clinical factors affecting functional decline and survival in
Japanese amyotrophic lateral sclerosis (ALS) patients. We constructed a multicenter …
Japanese amyotrophic lateral sclerosis (ALS) patients. We constructed a multicenter …
[HTML][HTML] A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis
R Nakamura, K Misawa, G Tohnai, M Nakatochi… - Communications …, 2020 - nature.com
Amyotrophic lateral sclerosis (ALS) is a devastating progressive motor neuron disease that
affects people of all ethnicities. Approximately 90% of ALS cases are sporadic and thought …
affects people of all ethnicities. Approximately 90% of ALS cases are sporadic and thought …
Next-generation sequencing of 28 ALS-related genes in a Japanese ALS cohort
R Nakamura, J Sone, N Atsuta, G Tohnai… - Neurobiology of …, 2016 - Elsevier
We investigated the frequency and contribution of variants of the 28 known amyotrophic
lateral sclerosis (ALS)-related genes in Japanese ALS patients. We designed a multiplex …
lateral sclerosis (ALS)-related genes in Japanese ALS patients. We designed a multiplex …
Neck weakness is a potent prognostic factor in sporadic amyotrophic lateral sclerosis patients
R Nakamura, N Atsuta, H Watanabe… - Journal of Neurology …, 2013 - jnnp.bmj.com
Objective To clarify the emergence of muscle weakness in regions of the body that affect
survival, and deterioration in activities of daily living (ADL) in amyotrophic lateral sclerosis …
survival, and deterioration in activities of daily living (ADL) in amyotrophic lateral sclerosis …
Structural MRI correlates of amyotrophic lateral sclerosis progression
J Senda, N Atsuta, H Watanabe… - Journal of Neurology …, 2017 - jnnp.bmj.com
Purpose Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain
degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical …
degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical …
A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN
H Watanabe, N Atsuta, A Hirakawa… - Journal of Neurology …, 2016 - jnnp.bmj.com
Objective To classify the patterns of functional decline in patients with sporadic amyotrophic
lateral sclerosis (ALS) and explore the genetic backgrounds that modified these patterns …
lateral sclerosis (ALS) and explore the genetic backgrounds that modified these patterns …
MRI mean diffusivity detects widespread brain degeneration in multiple sclerosis
We investigated the magnetic resonance imaging (MRI) findings of 32 multiple sclerosis
(MS) patients using voxel-based morphometry (VBM) and voxel-based analysis of white …
(MS) patients using voxel-based morphometry (VBM) and voxel-based analysis of white …
Age of onset differentially influences the progression of regional dysfunction in sporadic amyotrophic lateral sclerosis
D Yokoi, N Atsuta, H Watanabe, R Nakamura… - Journal of …, 2016 - Springer
The clinical courses of sporadic amyotrophic lateral sclerosis (ALS) show extensive
variability. Our objective was to elucidate how age of onset influences the progression of …
variability. Our objective was to elucidate how age of onset influences the progression of …