Obsessive-compulsive disorder (OCD) is a chronic psychiatric disorder that affects 2% of the
general population. Despite optimal cognitive-behavioral and pharmacologic therapy …

Background Thirty percent of patients with treatment-resistant depression (TRD) attempt
suicide at least once during their lifetime. However, it is unclear what the attempted and …

Compulsive behaviors are driven by repetitive urges and typically involve the experience of
limited voluntary control over these urges, a diminished ability to delay or inhibit these …

Context Obsessive-compulsive disorder (OCD) is a chronic psychiatric disorder that affects
2% of the general population. Even when the best available treatments are applied …

Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We
found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced …

BACKGROUND: Obsessive-compulsive disorder (OCD) is primarily conceived as an anxiety
disorder but has features resembling addictive behavior. Patients with OCD may develop …

Importance Patients with treatment-resistant depression (TRD) do not respond sufficiently to
several consecutive treatments for major depressive disorder. Deep brain stimulation (DBS) …

Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term
symptom relief for treatment-resistant depression (TRD). However, achieving stable recovery …

Tourette syndrome (TS) and obsessive-compulsive disorder (OCD) both are
neuropsychiatric disorders associated with abnormalities in dopamine neurotransmission …

Deep brain stimulation has been extensively studied as a therapeutic option for treatment-
resistant depression (TRD). DBS across different targets is associated with on average 60 …